Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
USERS' SCORE
Good
Based on 32 Reviews
8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
MSM (Methylsulfonylmethane)
2 g (2,000 mg)
*
Top Medical Research Studies
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
Most Useful Reviews
10
Remarkable results experienced
6 people found this helpful
Within a week, I was already noticing results. A month ago, I experienced significant knee pain while bending, and despite utilising pharmaceutical options, there was no improvement. After starting MSM from NOW on my sister’s recommendation (dosage: 2 tablets twice daily), my knee pain has completely vanished. I highly recommend this!
Read More
10
Joint pain relieved
5 people found this helpful
This product has truly helped me with joint problems. The pain in my joints has entirely subsided, along with the clicks in my knees and fingers. Even swelling on my fingers and one elbow has disappeared. However, if I skip days, the symptoms return. Over two years of using MSM, I believe it surpasses glucosamine with chondroitin.
Read More
9
Sports performance enhanced
5 people found this helpful
These supplements are perfect for joint support. After I began running, my knee started aching and crunching. Thankfully, this product provided almost immediate relief, allowing me to continue my sports without discomfort and even stimulating hair growth. Just remember to take probiotics to prevent thrush.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
- All Researches
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
8
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Read More
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 32 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Remarkable results experienced
6 people found this helpful
Within a week, I was already noticing results. A month ago, I experienced significant knee pain while bending, and despite utilising pharmaceutical options, there was no improvement. After starting MSM from NOW on my sister’s recommendation (dosage: 2 tablets twice daily), my knee pain has completely vanished. I highly recommend this!
Read More
10
Joint pain relieved
5 people found this helpful
This product has truly helped me with joint problems. The pain in my joints has entirely subsided, along with the clicks in my knees and fingers. Even swelling on my fingers and one elbow has disappeared. However, if I skip days, the symptoms return. Over two years of using MSM, I believe it surpasses glucosamine with chondroitin.
Read More
9
Sports performance enhanced
5 people found this helpful
These supplements are perfect for joint support. After I began running, my knee started aching and crunching. Thankfully, this product provided almost immediate relief, allowing me to continue my sports without discomfort and even stimulating hair growth. Just remember to take probiotics to prevent thrush.
Read More
10
Knee crunch relief
4 people found this helpful
The sulphur-based medication was beneficial; the crunching in my knees and fingers completely vanished, highlighting its efficacy in treating joint issues.
Read More
9
Improvement felt immediately
4 people found this helpful
This product has a commendable effect on my joints, and I noticed significant improvement shortly after starting. My knee pain has lessened substantially. The quality of this supplement is impressive, and I enjoy its taste and overall composition. At my age, joint care is crucial, leading me to recommend this product.
Read More
Frequently Asked Questions
10
Remarkable results experienced
6 people found this helpful
Within a week, I was already noticing results. A month ago, I experienced significant knee pain while bending, and despite utilising pharmaceutical options, there was no improvement. After starting MSM from NOW on my sister’s recommendation (dosage: 2 tablets twice daily), my knee pain has completely vanished. I highly recommend this!
9
Significant improvement noted
3 people found this helpful
After starting MSM, my knee pain dramatically decreased within just two weeks. I've been taking it for about eight months, and both my husband and I have noticed benefits not just in our joints but also improvements in hair health. We're pleased and plan to keep using it while enjoying cost savings from this site.
9
Quick effect
1 people found this helpful
Excellent! The roughness of my knee reduced significantly within a week. I take one pill after breakfast and another after dinner, and after two months, my knee feels excellent.
9
Pain relief
This supplement helped me; after about a month, I realised that my knees stopped hurting overnight.
0
No improvement
1 people found this helpful
Unfortunately, I did not see any improvement; my knees began to crunch even more.
10
Joint pain relieved
5 people found this helpful
This product has truly helped me with joint problems. The pain in my joints has entirely subsided, along with the clicks in my knees and fingers. Even swelling on my fingers and one elbow has disappeared. However, if I skip days, the symptoms return. Over two years of using MSM, I believe it surpasses glucosamine with chondroitin.
10
Knee crunch relief
4 people found this helpful
The sulphur-based medication was beneficial; the crunching in my knees and fingers completely vanished, highlighting its efficacy in treating joint issues.
7.5
Squeakiness resolved
3 people found this helpful
I noticed that my joints, particularly my knees, felt quite squeaky when using the stairs. However, it’s been less than a month since I began taking this supplement, and that issue has disappeared!
7.5
Less joint pain
2 people found this helpful
I recommend this supplement! The capsules are convenient as no dilution in water is required, making them easy to carry. Each capsule provides a daily dose of MSM, and I consume them alongside chondroitin and glucosamine. My knee and joint pain have noticeably reduced.
9
Great results
1 people found this helpful
I’ve been taking this wonderful sulfur supplement for two years with other vitamins and Omega-3. My knees stopped crunching, hair loss decreased, and my nails became stronger. I’m very pleased; you won’t regret it!
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
References
- Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15132995
- Tennent DJ, Hylden CM, Kocher BK, Aden JK, Johnson AE. A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees. US Army Med Dep J. 2017.
- Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, et al. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J. 2013;12:154. doi:10.1186/1475-2891-12-154
- Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. doi:10.1186/1472-6882-11-50
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.
